WHO Classification

The World Health Organization Classification for Tumours of the Central Nervous System

Astrocytic tumours

WHO GRADE II WHO GRADE I PLEOMORPHIC XANTHOASTROCYTOMA PILOCYTIC ASTROCYTOMA SUBEPENDYMAL GIANT CELL ASTROCYTOMA ASTROCYTOMA WHO GRADE III ANAPLASTIC ASTROCYTOMA WHO GRADE IV GLIOBLASTOMA MULTIFORME

Oligodendroglial Tumours



OLIGODENDROGLIAL TUMOURS OLIGODENDROGLIOMA GRADE II ANAPLASTIC OLIGODENDROGLIOMA GRADE III Mixed Gliomas

Mixed oligoastrocytoma (WHO grade II)

Anaplastic (malignant) oligoastrocytoma (WHO grade III)

Others (e.g. ependymo-astrocytomas)

Polar spongioblastoma (WHO grade IV)

Astroblastoma (WHO grade IV)

Gliomatosis cerebri (WHO grade IV)

Choroid plexus papilloma

Choroid plexus carcinoma (anaplastic choroid plexus papilloma)

Gangliocytoma

Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos)

Ganglioglioma

Anaplastic (malignant) ganglioglioma

Desmoplastic infantile ganglioglioma

Central neurocytoma

Dysembryoplastic neuroepithelial tumour

Olfactory neuroblastoma (esthesioneuroblastoma)

Pineocytoma

Pineoblastoma

Mixed pineocytoma/pineoblastoma

Medulloepithelioma

Primitive neuroectodermal tumours with multipotent differentiation

medulloblastoma

variants: medullomyoblastoma, melanocytic medulloblastoma, desmoplastic medulloblastoma

cerebral primitive neuroectodermal tumour

Neuroblastoma

variant: ganglioneuroblastoma

Retinoblastoma

Ependymoblastoma

Neuroepithelial Tumours of the CNS

Non-neuroepithelial Tumours of the CNS

Pituitary adenoma

Pituitary carcinoma

Craniopharyngioma

Primary malignant lymphomas

Plasmacytoma

Granulocytic sarcoma

Others

Germinoma

Embryonal carcinoma

Yolk sac tumour (endodermal sinus tumour)

Choriocarcinoma

Teratoma

Mixed germ cell tumours

Meningioma

variants: meningothelial, fibrous (fibroblastic), transitional (mixed), psammomatous, angiomatous, microcystic, secretory, clear cell, chordoid, lymphoplasmacyte-rich, and metaplastic subtypes

Atypical meningioma

Anaplastic (malignant) meningioma

Benign Mesenchymal

Osteocartilaginous tumours

Lipoma

Fibrous histiocytoma

Others

Chondrosarcoma

Hemangiopericytoma

Rhabdomyosarcoma

Meningeal sarcomatosis

Others

Diffuse melanosis

Melanocytoma

Malignant melanoma

Variant meningeal melanomatosis

Malignant lymphoma

Plasmacytoma

Granulocytic sarcoma

Tumours of Uncertain Histogenesis

Hemangioblastoma (capillary hemangioblastoma)

Schwannoma (neurinoma, neurilemoma)

Cellular, plexiform, and melanotic subtypes

Neurofibroma

Circumscribed (solitary) neurofibroma

Plexiform neurofibroma

Malignant peripheral nerve sheath tumour (Malignant schwannoma)

Epithelioid

Divergent mesenchymal or epithelial differentiation

Melanotic

Rathke cleft cyst

Epidermoid

Dermoid

Colloid cyst of the third ventricle

Enterogenous cyst

Neuroglial cyst

Granular cell tumour (choristoma, pituicytoma)

Hypothalamic neuronal hamartoma

Nasal glial herterotopia

Plasma cell granuloma

Paraganglioma (chemodectoma)

Chordoma

Chodroma

Chondrosarcoma

Carcinoma

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